In updating the package label for warfarin last week, the Food and Drug Administration alerted patients that genetic testing could be used customize their dosages. The agency said the change “highlights the opportunity” for doctors to use genetic testing when prescribing warfarin. But it offered no advice about how to do so.
Find the meta-analysis that prompted this decision. The studies show that patients with a few genetic types need less warfarin than most.
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Practical Articles and News
The FDA declined to recommend any particular warfarin dosing algorithm.
Clinical Trials for Patients
A clinical trial now underway compares pharmacogenomic dosing with a decision-model algorithm for warfarin dosing.
Patient Education Materials
It’s probably too soon to give your patients a brochure about gene testing and warfarin. But you can provide something that tells how you normally choose the dose.
Posted by Cranky Aged Mama
Posted by Cranky Aged Mama
Posted by Cranky Aged Mama
