Are seeds of psychosis sown in utero?

Someone’s search term schizophrenia gestation alerts us to several new studies about the influence of prenatal factors, especially infection, on the risk of psychosis during childhood or adulthood.

RESULT: Targeting Cognition in Schizophrenia Research: From Etiology to Treatment
American Journal of Psychiatry

The second half of this editorial in the American Journal of Psychiatry points out a new study that examines prenatal exposure to infection (specifically, influenza and Toxoplasma) as a cause of cognitive dysfunction in schizophrenia—one of the first to do so.

TIP: If you see a citation to another study that hasn’t turned up in your original search, and there’s no automatic link to it in the citation list, you can probably still find it on SearchMedica. Try a separate search using several terms in the citation title as your query.

We found the study mentioned in the editorial using the term maternal infection schizophrenia executive function.

RESULT: Prenatal Exposure to Maternal Infection and Executive Dysfunction in Adult Schizophrenia
American Journal of Psychiatry

Another result, a registry study from Finland, posits an interaction between prenatal infection, heredity and schizophrenia.

RESULT: Evidence for an Interaction Between Familial Liability and Prenatal Exposure to Infection in the Causation of Schizophrenia
American Journal of Psychiatry

Scroll a little farther down for a British study that finds a link between impaired prenatal growth and symptoms of psychosis at age 12.

RESULT: Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds: the ALSPAC cohort
British Journal of Psychiatry

IN THE JOURNALS
What have other clinicians been finding on SearchMedica?

Search term: Tourette

The first prevalence study in the US finds Tourette syndrome in about three of every 1,000 children—usually mild but often comorbid with ADHD or OCD.

RESULT: Prevalence of Diagnosed Tourette Syndrome in Persons Aged 6-17 Years: United States, 2007
MMWR

Search term: traumatic neurosis

A new review alerts doctors to the increased risk of cardiovascular disease in people who have PTSD, especially firefighters, police officers and, of course, soldiers.

RESULT: Is posttraumatic stress disorder related to development of heart disease? An update
Cleveland Clinic Journal of Medicine

TIP: Does your list of results grow smaller with every search?

SearchMedica has a “drill-down” feature that narrows searches with every successive click.

If you want to broaden your searches or try again with a different query, click on the SearchMedica logo and start again from the home page.

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