Quebec doctors report the rapid emergence of H1N1 resistance to oseltamivir in a father who was given the drug in a failed attempt to prevent him from catching the pandemic flu from his infected child. They urge that prophylactic doses be raised to therapeutic levels as soon as symptoms develop. Monitoring for the mutation that causes this resistance (in avian and seasonal as well as pandemic H1N1) is also crucial.
RESULT: Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis
New England Journal of Medicine | Nov 11, 2009
The CDC quickly posted online ahead of print this report of naturally arising resistance due to a different mutation found in an American teenager who took a flight to Hong Kong, arrived ill with the pandemic flu, and refused treatment with oseltamivir. H1N1 viruses with this mutation appear to replicate rapidly, and there is “great concern” that resistant strains may become dominant.
RESULT: Oseltamivir-Resistant Influenza A Pandemic (H1N1) 2009 Virus, Hong Kong, China
Emerging Infectious Diseases | Oct 20, 2009
Search: tamiflu
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OTHER RECENT SEARCHES ON SEARCHMEDICA
Search: hypertension
RESULT: Cardiovascular and Metabolic Predictors of Progression of Prehypertension Into Hypertension: The Strong Heart Study
Hypertension | Nov 1, 2009
A prospective study of Native Americans in Arizona, North and South Dakota, and Oklahoma has shown that in addition to diabetes and initial systolic blood pressure, increased left ventricular (LV) mass is a strong predictor of progression from prehypertension to hypertension. There’s a chicken-and-egg question, however: Is the higher LV mass merely an earlier indicator of the underlying problem—as yet undetected by the blood pressure measurement—or an actual risk factor for hypertension?
RESULT: Newly Reported Hypertension After Military Combat Deployment in a Large Population-Based Study
Hypertension | Nov 1, 2009
For military personnel, deployment to Iraq or Afghanistan appears to be a stress-related risk factor for the development of new hypertension.
Search: lower respiratory tract infection
RESULT: Risk Factors for Lower Respiratory Tract Infection Death Among Infants in the United States, 1999-2004
Pediatrics | Oct 1, 2009
Among infants with a normal birth weight, those born to Native American/Alaskan or black mothers are at increased risk for lower respiratory tract infection. The unanswered question is why.
Search: headache
RESULT: Prevalence of Depression Symptoms in Outpatients with a Complaint of Headache
Journal of the American Board of Family Medicine | Nov 1, 2009
About one-third of patients who appear at a primary care office complaining of headache also have depression, according to this study, compared to only 10% of those who come in for another reason. The authors suggest screening all people who have chronic headaches for depression.
RESULT: Health Care Assistants in Primary Care Depression Management: Role Perception, Burdening Factors, and Disease Conception
Annals of Family Medicine Medicine | Nov 1, 2009
Follow-up by health care assistants using structured telephone interviews proved actually better than usual care for depression, according to this study of primary care practices in Germany. The staff found this an additional burden but preferred it to administrative tasks and were willing to undertake it.
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SEARCH TIP: That other option: The entire Web
Someone wrote in to thank us for a useful result about headache found using the option “The entire Web” (rather than “Recommended medical sites,” which is the default).
RESULT: Headache: Hope Through Research
National Institute of Neurological Diseases and Stroke
The gratitude is misplaced. This page for a general audience, including descriptions of research, does not appear among our sites recommended for a physician audience.
This option is useful for searching the general news. But SearchMedica’s Advisory Board has not approved its content and it cannot be recommended as a source of medical information.
