Chelation and autism: End of the line?

October 7, 2008

NIMH pulls the plug on chelation therapy trial for autism

A clinical trial of chelation therapy in autistic children with detectable blood levels of mercury has been cancelled by the NIMH.

The agency explained that a suggested link between mercury-containing vaccines and autism has not been proven.

Also, rat studies suggested that chelation therapy might be dangerous in the absence of blood lead.

No children had been enrolled in the clinical trial before it was cancelled.

All of Medicine tab

This month’s edition of Archives of Disease in Childhood compiles a recent study finding no link between the MMR vaccine and autism with letters responding to that study.

Practical Articles/News

A recent article in Psychiatric Times reviews complementary therapies for autism.

Evidence-based Medicine

Placebo worked just as well as chelation therapy in reducing distress among people concerned about the mercury in their dental fillings, according to an old randomized study found in this article category.

(The chelating drug did elute mercury, but people on placebo scored equally on anxiety and somatization measures after treatment.)


Flu shots, cradle to college

October 7, 2008

CDC says far too few tots get influenza vaccine, urges shots from 6 months

All children older than six months should get the flu shot, according to a new advisory from the Centers for Disease Control and Prevention.

Infants between six and 23 months old are at particular risk of hospitalization with influenza. Yet last year only one in five tots in this age range received the influenza vaccine.

The agency is paving the way for your conversation with parents, using a major mass media campaign that targets consumer health blogs and parenting websites.

Twenty two leading agencies, including the American Academy of Family Physicians and the American Academy of Pediatrics, joined last month in a new alliance to bolster public confidence in immunization.

Infants younger than six months can be protected from influenza if the expectant mother gets a flu shot, according to a new study in the New England Journal of Medicine.

Practice Guidelines

Quickly find the latest guidelines on prevention and treatment of influenza in children.

Patient Education

Here’s the place to find reliable information for parents on the question of preventing and treating flu in their kids.


How not to eat your way to diabetes

August 12, 2008

Calories—not sugar, carbs, or fat—cause type 2 diabetes in those at risk

What people eat controls what they weigh, and that (setting aside genes and exercise) seems to determine the risk of type 2 diabetes—not the types of macronutrients themselves. That’s the upshot of two new studies in the Archives of Internal Medicine, according to a review in the same issue.

It’s not the sugar in soft drinks or juices but the poundage they so easily add that predisposes to type 2 diabetes, according to a study of young African-American women in the July 28 issue of Archives.

It was probably weight loss per se, not the low-fat or high-fiber diet, that reduced glycemia among postmenopausal women in the other study.

Which is best for weight loss: low carbs, low fat, or the Mediterranean diet? Depends on the patient’s underlying risk profile. The latter may be best for people at risk of diabetes, according to another new report, this one in the New England Journal of Medicine.

Related searches

Mediterranean diet diabetes

obesity children juice

menopause metabolic syndrome testosterone

Research/Reviews

How much exercise do patients need to maintain weight loss? Find more new reports in this article category.

Patient Education

Look in this category for trustworthy information for patients about physical activity and diabetes.


Losing strategy: Purge, don’t binge

June 24, 2008

To create an eating-disordered teen: Turn on MTV, then call her chubby

The largest, longest-running study of disordered eating among adolescents and teenagers shows that about 10% of girls and 3% of boys binge eat, purge, or both at least weekly in order to lose weight. Data come from about 11,000 children of women in the national Nurses Health Study II.

A large group of girls who purge without binge eating are going unrecognized, the authors suggest, because they don’t fit current diagnostic criteria.

The study set out to define predictors of disordered eating. These include
* teasing about weight,
* maternal history of eating disorder (but only for adolescent girls), and
* also for girls, wanting to look like young women in the media.

They urge that young women at risk should be educated about issues of media and body image.

Related Searches

bulimia nervosa

binge eating disorder

Research/Reviews
The results show that adolescent girls are at greater risk if their mothers were affected. What is the evidence about heritability of eating disorders?

Evidence-based Articles
The new study adds to already solid evidence that teasing about weight breeds eating disorders and other emotional problems.


Totally awesome!!!! (But is it oozing?)

June 24, 2008

Increase in body piercings causes headaches for health providers

Doctors should prepare for the consequences as piercing of body parts other than earlobes gains in popularity, according to a government-sponsored study in the UK.

About one in ten adults has had something other than an earlobe or two pierced, the study found. Navels were the most common site (reported by one teen girl in three, with complications in one-third of those cases). Oral piercings are on the increase.

A startling one piercing in ten took place outside a specialist piercing shop. There was at least one report of piercing by self or a friend for every body part mentioned in the study, including nipples and genitals.

One body piercing in 100 ended in hospitalization.

These data confirm and expand on similar results from the United States.

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auricular perichondritis

tattoos

Research/Reviews

There are numerous reports about the risks that body piercing may cause viral hepatitis.


BPD is a learning disorder. Really.

May 13, 2008

It helps to teach BPD patients how their actions affect others

A long-term randomized trial may herald the end of the era of denial and hopeless desperation surrounding borderline personality disorder (BPD).

One group of patients underwent the structured “mentalization” therapy pioneered by Bateman and Fonagy. The others had treatment as usual (psychiatric consultation, medication, and hospitalization).

Five years later, subjects in the first group were significantly less suicidal and more functional. They also were using fewer clinical resources and took less medication.

A different randomized trial published last month validates an adjunctive training system that boosts the results of structured therapies already shown effective for BPD.

Practical Articles/News
Has anyone looked for an actual association between BPD and cognitive deficits?

Research/Reviews
Which is the best approach to frank suicidality in a BPD patient?

Related searches

BPD DBT

schema-focused therapy


FDA approves Abilify for adolescents with schizophrenia

November 27, 2007

Based on the recent multinational study showing a significant benefit for adolescents with schizophrenia, the FDA has approved aripirazole (Abilify) for kids aged 13 to 17. The study showed significant improvements over placebo, and a discontinuation rate of only about 4% over six weeks.

In that clinical study involving more than 300 adolescents in 13 countries, the most common side effects were extrapyramidal symptoms and drowsiness. About 5% of the teens gained at least 7% over their baseline weight.

The action closely follows approval of risperidone for kids with schizophrenia only two months ago.

Learn more quickly with SearchMedica’s content categories:

Practical Articles and News
Find guidance for encouraging adherence despite body-image issues in young schizophrenia patients.

Clinical Trials for Patients
A new clinical trial (but not for adolescents) is comparing Abilify head-to-head with injectable Risperdal to test the effects on adherence. (The hypothesis favors Risperdal).