Next: Genetic profiles on Facebook?

November 4, 2008

Project seeks volunteers to make their DNA profiles public for researchers

People may be thinking about genetic testing again, after reading recent press reports about the Personal Genome Project.

Late last month, the first few volunteers saw some of their genetic information made public on the Internet.

This effort seeks 100,000 volunteers willing to have their DNA sequenced, databased, and stored online, along with identifying medical and personal information, in order to speed the development of medical genomics.

For a quick brush-up on the pros and cons of reading your own gene map, the search term
risks genetic testing
offers some balanced reflections.

In some cases, diagnosis by history and examination has already given way to genetic testing. For instance, it’s now time to think “genotype first” when you see a child with a developmental issue, said an editorial in the New England Journal of Medicine a few weeks ago.

See what you can find by searching through the article categories with the search term “genetic testing”.

Evidence-based Articles

Scroll down first page of results for genetic testing to find a recent systematic review in JAMA about genetic testing for chronic adult diseases.

Practical Articles/News

This category holds a news article showing that an inconclusive genetic result can be as distressing as a positive one.

Patient Education

Scroll down here to find a Mayo Clinic blog for patients who may want to learn more about the topic on their own time.


New “epidemic”: Accidental suicides

August 12, 2008

Meds + booze + street drugs @ home = sharp rise in accidental deaths

Fatal medical errors skyrocketed in the two decades after 1983—but not in hospitals. The increase overwhelmingly involved people who died at home after mixing medicines, street drugs, and alcohol. Death rates in this category rose 30-fold between 1983 and 2003.

Oddly, accidental deaths from any of those three substances in isolation did not increase markedly during the same period.

Don’t just blame substance abusers: At-home deaths involving medications but not street drugs or alcohol increased nearly six-fold during those two decades.

The most common victims were men between the ages of 40 and 59.

The study of death certificates is newly published in the Archives of Internal Medicine.

The increase in these deaths has been accelerating. The article urges medical professionals to address the problem by:

* assessing how well patients can manage their own medicines
* taking pains to educate them about the risks of their medications and
* keeping track of their progress

Related searches

screening alcohol use

self-report alcohol drug

Research/Reviews

What’s the best way to talk with patients about their new prescriptions? We found interesting insights with the query communication risks.

Practical Article/News

In a recent review in Psychiatric Times, a Yale University psychiatrist warns about an emerging problem among aging baby boomers: substance abuse.


When enough is too much

July 8, 2008

New success measures for late-stage cancer treatment evoke tough questions

Among 11 candidate biomarkers under study in the UK MRC FOCUS trial, the largest-yet trial of metastatic colorectal cancer, levels of topoisomerase-1 (Topo1) appears to be the only one that predicts response to irinotecan in combination with fluorouracil. Patients with a high response to Topo1 gained a median 5.3 months of survival.

In the other arm of the trial, Topo1’s predictive value for fluoruracil-oxaliplatin was suggestive but not significant, at p = 0.05.

Oncologists have been wondering aloud how to communicate with patients when (as in the study above), continuing chemotherapy offers only a few more months of life at the cost of adverse effects.

“When is enough enough?” ask the authors of an article in a recent issue of the Journal of the American Medical Association

Another recent report, this one in the Journal of Clinical Oncology,assesses prognostic factors for 2-month survival among hospitalized patients with advanced solid tumors. A combination of factors proved most predictive:

* Karnofsky index
* Number of metastatic sites
* Low serum albumin, and
* LDH concentration

The patient’s desire to continue treatment was also associated with survival.

Evidence-based Articles

A recent article in BMJ Clinical Evidence by authors from the UK and Canada ponders whether adverse effects data from major trials like the one above can be relevant in community practice, and how to make them more so.

Related searches

topoisomerase-1 irinotecan

chemotherapy decision aids